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KMID : 0061119820100000059
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Bulletin of the Clinical Research Institute
1982 Volume.10 No. 0 p.59 ~ p.60
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Corneal Endothelial Cell Loss During Intraccular Lens Insertion in Rabbits
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Lee Chan-Ju
Kim Jae-Ho
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Abstract
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Adequate founction of the endothelial cell is necessary fora perfectly clear cornea. Endothelial function is endangered in all intraocular surgery, but especially in IOL implantation surgery. This endothelial cell damage is attributed mainly to greater mechanical trauma to the endothelium at the time of IOL insertion and can be prevented by the use of air or sodium hyaluronate in anterior chamber not to contact of the IOL with the endothelial surface.
This experiment was carried out to examine the endothelial changes in New Zealand white rabbits which underwent extracapsular cataract extraction and intentionally traumatic implantation of Shearing J-loop posterior chamber intraocular lens.
The animals were divided into two main groups;
Extracapsular cataract extraction group as control, and intraocular implanta lion group as experimental group. Extracapsular cataract extraction was performed in two ways;
a) Extraction after air injection into anterior chamber.
b) Extraction after sodium hyaluronate injection into anterior chamber. Intraocular lens implantation was performed in each of following four different ways;
a) Insertion through an air-filled anterior chamber without endothelial contact.
b) Insertion through an air-filled anterior chamber with intentional endothelial contact.
c) Insertion through n sodium hyaluronate-filled anterior chamber without endothelial contact.
d) Insertion through a sodium hyaluronate-filled anterior chamber with intentional endothelial contact.
The corneal endothelial changes of all animals were observed at 24 hours after operation by specular microscope and scanning electron microscope. We also examined the ciliary bodies of eyes containing implants histopathological 1Y to detect the changes of ciliary body to lens loop at 2nd, 4th and `12th week.
This study indicate that the use of air or sodium hyaluronate in the anterior chamber can help to prevent endothelial cell loss and that sodium hyaluronate is for superior to air tested in preventing endothelial damage due to intraocular lens
contact.
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